No, not that kind of clock problem. I just finished rebooting Mindy with the "nohz=off" kernel setting and that appears to have solved at least 75% of my problem. I can now play music with my Roku, copy data to the server, download a Podcast on iTunes and still hear basically unbroken audio notifications from my WinXP virtual machine over Remote Desktop. (Granted I have gigabit ethernet), but before any 2 of those would cause problems.
Will it stay? If so, I'll post a bit of information on what I did for those of you searching for the same problems I'm seeing.